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Rhodes, Christopher
One or more keywords matched the following items that are connected to Rhodes, Christopher
Item TypeName
Concept Appetite Regulation
Concept Exocytosis
Concept Gene Expression Regulation
Concept Regulatory Sequences, Nucleic Acid
Concept Up-Regulation
Concept Gene Expression Regulation, Developmental
Concept Sterol Regulatory Element Binding Protein 1
Concept Down-Regulation
Concept Gene Expression Regulation, Enzymologic
Concept Extracellular Signal-Regulated MAP Kinases
Concept Gene Expression Regulation, Neoplastic
Academic Article Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
Academic Article A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
Academic Article The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Academic Article Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
Academic Article Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Academic Article Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
Academic Article Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
Academic Article How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats.
Academic Article Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
Academic Article Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
Academic Article A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
Academic Article Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.
Academic Article Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
Academic Article A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
Academic Article Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
Academic Article Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
Academic Article Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
Academic Article Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
Academic Article Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population.
Academic Article A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
Academic Article Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
Academic Article Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
Academic Article Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
Academic Article Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells.
Academic Article Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
Academic Article Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
Academic Article Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.
Academic Article Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
Academic Article A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
Academic Article Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
Academic Article Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.
Academic Article Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
Academic Article Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Academic Article Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Academic Article The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
Academic Article Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
Academic Article Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
Academic Article Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
Academic Article Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets.
Academic Article FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
Academic Article PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
Academic Article Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
Academic Article Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
Academic Article Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
Academic Article Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
Academic Article The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
Academic Article Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
Academic Article Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
Academic Article Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet.
Academic Article Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Academic Article Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Academic Article Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala.
Academic Article ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
Academic Article Islet autoantigens: structure, function, localization, and regulation.
Academic Article Characterization of the promoter for the rat and human link protein gene.
Academic Article Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells.
Academic Article The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.
Academic Article Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus.
Academic Article Ca(2+)-regulated serine protease associated with the nuclear scaffold.
Academic Article Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini.
Academic Article The c-propeptide of type II procollagen binds to the enhancer region of the type II procollagen gene and regulates its transcription.
Academic Article Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene.
Academic Article Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.
Academic Article Leptin action in the forebrain regulates the hindbrain response to satiety signals.
Academic Article Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Academic Article Free radicals, metals and antioxidants in oxidative stress-induced cancer.
Academic Article Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
Academic Article Identification of the Novel Tooth-Specific Transcription Factor AmeloD.
Academic Article Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.
Academic Article miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
Academic Article Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology.
Academic Article Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
Academic Article Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
Academic Article Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension.
Academic Article Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.
Academic Article Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.
Academic Article A fluorescent timer reporter enables sorting of insulin secretory granules by age.
Academic Article Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
Concept Regulatory-Associated Protein of mTOR
Grant Mitogenic Signal Transduction in Pancreatic Beta-Cells
Grant Metabolic Control of Insulin Exocytosis
Grant Central Control of Pancreatic Islet Function
Grant Western Region Islet Study Group
Grant Metabolic Control of Proinsulin Biosynthesis Translation
Grant Metabolic Control of Proinsulin Biosynthesis Translation
Academic Article Response by Walters et al to Letter Regarding Article, "SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension".
Search Criteria
  • regulated
  • exocytosis